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Valosin-containing protein (VCP), which belongs to the AAA (ATPase associated with diverse cellular activities) proteins, has been shown to colocalize with abnormal protein aggregates, such as nuclear inclusions of Huntington disease and Machado-Joseph disease, and Lewy bodies in Parkinson disease. It is suggested that VCP may be a potential therapeutic target for the treatment of these neurodegenerative diseases. Professor Akira Kakizuka and Dr. Hori synthesized novel naphthalene derivatives with VCP inhibitory activity. The naphthalene derivatives are able to regulate VCP activity and subsequently suppress the degeneration of neural cells. 


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